Prevention Research in Mid-Life Adults (R01 Clinical Trial Optional) | PA 18 849

Opportunity Information: Apply for PA 18 849

Prevention Research in Mid-Life Adults (R01 Clinical Trial Optional) is a National Institutes of Health (NIH) funding opportunity designed to spur research focused on adults in mid-life, specifically ages 50 to 64. The central goal is to generate evidence that helps people maintain health and overall well-being as they age, with an emphasis on preventing the onset of illness, functional decline, and disability later in life. In practical terms, the NIH is looking for research that can identify what works in mid-life to set up healthier trajectories into older age, whether that involves understanding risk and protective factors, developing or testing preventive approaches, or producing actionable findings that can guide public health and clinical prevention strategies.

The announcement uses the R01 mechanism, which typically supports well-developed, hypothesis-driven projects with a clear plan, strong methods, and the potential for meaningful impact. The "Clinical Trial Optional" designation means applicants may propose studies that include clinical trials, but they are not required to do so. This leaves room for a broad range of prevention research designs, including observational and longitudinal studies, intervention development, pragmatic or community-based prevention efforts, and trials where appropriate, as long as the work is centered on prevention and on the 50 to 64 age group.

This opportunity is categorized as a discretionary grant and is aligned with the health and education funding activity areas. It is associated with CFDA numbers 93.361 and 93.866, reflecting NIH program areas connected to prevention and health-related research. The FOA number is PA 18 849, and it was originally created on 2018-07-05. The listing notes an original closing date of 2021-09-07. While no award ceiling and no expected number of awards are specified in the provided data, applicants would typically confirm current budget guidance, submission dates, and application requirements directly in the full FOA and any active notices or renewals tied to it.

Eligibility is intentionally broad to encourage participation from many sectors that can contribute to mid-life prevention research. Standard eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; Native American tribal organizations that are not federally recognized; nonprofits with and without 501(c)(3) status (outside of higher education institutions); for-profit organizations (other than small businesses); small businesses; and other entities. The FOA also explicitly highlights additional eligible applicant types, including Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; U.S. territories or possessions; tribal governments that are not federally recognized; and even non-U.S. (foreign) organizations. Taken together, this signals an interest in reaching diverse populations and settings, and in supporting research teams that can address prevention needs across different communities and systems.

In summary, this NIH FOA supports rigorous prevention research aimed at mid-life adults (50 to 64) to improve health and functioning as people move into older age. It funds R01-level projects and allows, but does not require, clinical trials. It is open to a wide range of applicants across academia, government, nonprofit, community, tribal, and private-sector organizations, including U.S. territories and foreign entities, reflecting a broad push to develop practical knowledge that can reduce later-life disease burden and disability by intervening earlier in the life course.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Prevention Research in Mid-Life Adults (R01 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361, 93.866.
• This funding opportunity was created on 2018-07-05.
• Applicants must submit their applications by 2021-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PA 18 849

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