Opportunity Information: Apply for RFA AT 24 011
This funding opportunity (RFA-AT-24-011) from the National Institutes of Health supports new Demonstration Projects within the NIH-DoD-VA Pain Management Collaboratory (PMC) under the HEAL Initiative. The core aim is to fund efficient, large-scale pragmatic clinical trials and/or implementation science projects that test non-opioid approaches to pain management for U.S. veterans, active-duty military personnel, and their families, including attention to pain-related comorbid conditions. The work is intended to produce practical, real-world evidence that can be adopted in the health systems that serve these populations, rather than remaining confined to highly controlled research environments.
The award uses a UG3/UH3 phased cooperative agreement structure and requires a clinical trial. In practice, this means applicants propose a two-stage project where the initial UG3 phase is typically used to finalize key start-up activities (for example, confirming feasibility, refining protocols, establishing site readiness, and meeting defined milestones), and the UH3 phase supports full implementation and execution of the pragmatic trial and/or implementation study once those milestones are met. Because this is a cooperative agreement, NIH involvement is more hands-on than in a standard grant mechanism, with NIH program staff expected to have substantial scientific and programmatic involvement during the project.
A defining feature of the opportunity is that projects must be conducted within the existing PMC infrastructure. The PMC includes a Coordinating Center established in 2017 that provides national leadership and technical expertise across PMC studies. Awardees can expect coordinated support related to pragmatic trial methods, implementation science approaches, data and informatics considerations, regulatory and operational alignment across sites, and other common challenges that arise when conducting large-scale studies in military and veteran health care contexts. The overall intent is to accelerate high-quality, scalable research by leveraging this shared infrastructure instead of building trial operations from scratch.
The topic focus is squarely on non-opioid pain management solutions, aligning with the HEAL Initiative, an NIH-wide effort to address the opioid crisis partly by identifying and validating effective pain treatments that reduce reliance on opioids. In addition, the National Center for Complementary and Integrative Health (NCCIH) is highlighting a whole person approach to pain management as a priority emphasis, meaning applicants are encouraged to consider pain in the broader context of physical, behavioral, and social factors and how integrated care strategies may improve outcomes. Partnering NIH Institutes, Centers, and Offices may also bring additional priority areas as long as they include pain as a component, so projects that thoughtfully connect pain management with relevant comorbidities may be particularly responsive.
Eligibility is broad across public, nonprofit, and private sectors. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and federally recognized Native American tribal governments and certain tribal organizations. The announcement also explicitly calls out additional eligible groups such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible agencies of the federal government.
Foreign participation is constrained. Non-domestic (non-U.S.) entities are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply. However, foreign components, as defined in the NIH Grants Policy Statement, are allowed, which generally means a U.S.-based applicant may include certain foreign elements when clearly justified and allowable under NIH policy.
Administratively, the opportunity is categorized as a discretionary program and uses the cooperative agreement funding instrument type in the health activity category, with CFDA numbers 93.213, 93.273, and 93.866. The original application closing date listed is 2024-11-07, and the notice was created on 2024-08-09. Award ceiling and expected number of awards are not specified in the provided listing, so applicants would need to consult the full NOFO for budget limits, project period expectations, and any caps or set-asides.
Overall, the opportunity is designed for teams that can run a required clinical trial in real-world military and veteran care settings, using pragmatic and/or implementation science methods, and that can work within the PMC framework to generate results that are credible, operationally relevant, and ready for adoption as non-opioid pain management solutions.Apply for RFA AT 24 011
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "HEAL Initiative: NIH-DOD-VA Pain Management Collaboratory Pragmatic and/or Implementation Science Demonstration Projects ((UG3/UH3) Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.273, 93.866.
- This funding opportunity was created on 2024-08-09.
- Applicants must submit their applications by 2024-11-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity is NIH RFA-AT-24-011, which supports new Demonstration Projects within the NIH-DoD-VA Pain Management Collaboratory (PMC) under the HEAL Initiative. It is intended to fund efficient, large-scale pragmatic clinical trials and/or implementation science projects focused on non-opioid approaches to pain management.
What is the main goal of the program?
The main goal is to generate practical, real-world evidence on non-opioid pain management approaches that can be adopted in the health systems serving U.S. veterans, active-duty military personnel, and their families. The emphasis is on results that translate into routine care, not findings limited to highly controlled research settings.
Who is the target population for the research?
The target population includes U.S. veterans, active-duty military personnel, and their families. The opportunity also notes attention to pain-related comorbid conditions affecting these groups.
What kinds of projects are supported?
The opportunity supports Demonstration Projects that are pragmatic clinical trials and/or implementation science projects testing non-opioid approaches to pain management, including consideration of pain-related comorbidities where relevant.
Is a clinical trial required?
Yes. The award uses a UG3/UH3 phased cooperative agreement structure and requires a clinical trial.
What does the UG3/UH3 phased structure mean?
Applicants propose a two-stage project. The UG3 phase is typically used for start-up and readiness work such as confirming feasibility, refining protocols, establishing site readiness, and meeting defined milestones. The UH3 phase supports full implementation and execution of the pragmatic trial and/or implementation study after UG3 milestones are met.
What happens if UG3 milestones are not met?
The opportunity describes the UG3 phase as a milestone-driven stage that precedes the UH3 implementation phase. Advancement to UH3 is described as occurring once defined milestones are met, implying that failure to meet milestones could affect transition to the UH3 phase.
What is a cooperative agreement and how is it different from a standard grant?
This opportunity uses a cooperative agreement mechanism, meaning NIH program staff are expected to have substantial scientific and programmatic involvement during the project. This is more hands-on NIH involvement than what is typical for a standard grant mechanism.
Does the project have to be conducted within a specific network or infrastructure?
Yes. A defining feature is that projects must be conducted within the existing PMC infrastructure rather than building trial operations independently from scratch.
What is the Pain Management Collaboratory (PMC)?
The PMC is a NIH-DoD-VA collaboratory that includes a Coordinating Center established in 2017. It provides national leadership and technical expertise across PMC studies, especially for large-scale pragmatic and implementation-focused research in military and veteran health care contexts.
What support does the PMC Coordinating Center provide to awardees?
Awardees can expect coordinated support related to pragmatic trial methods, implementation science approaches, data and informatics considerations, and regulatory and operational alignment across sites, along with other common challenges that arise in large-scale studies in military and veteran care settings.
What research topic areas are emphasized?
The focus is on non-opioid pain management solutions aligned with the HEAL Initiative. The opportunity also highlights attention to pain-related comorbid conditions and encourages approaches that are practical for real-world adoption in military and veteran health systems.
How does this opportunity connect to the HEAL Initiative?
It aligns with the HEAL Initiative, an NIH-wide effort to address the opioid crisis, in part by identifying and validating effective pain treatments that reduce reliance on opioids.
Is there an emphasis on complementary or integrative health approaches?
The National Center for Complementary and Integrative Health (NCCIH) highlights a "whole person" approach to pain management as a priority emphasis, encouraging applicants to consider pain within physical, behavioral, and social contexts and how integrated care strategies may improve outcomes.
Can projects include comorbidities or other priority areas beyond pain?
Yes, partnering NIH Institutes, Centers, and Offices may bring additional priority areas as long as they include pain as a component. Projects that connect pain management with relevant comorbidities may be particularly responsive.
Who is eligible to apply?
Eligibility is broad across public, nonprofit, and private sectors. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status, other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; federally recognized Native American tribal governments; and certain tribal organizations.
Are specific types of institutions or organizations explicitly mentioned as eligible?
Yes. The announcement explicitly calls out groups including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible agencies of the federal government.
Are non-U.S. (foreign) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply.
Are any foreign activities allowed at all?
Yes. Foreign components (as defined in the NIH Grants Policy Statement) are allowed when clearly justified and allowable under NIH policy. In general, this means a U.S.-based applicant may include certain foreign elements if they fit NIH policy requirements.
What is the funding instrument type?
The opportunity uses a cooperative agreement funding instrument type and specifically the UG3/UH3 phased cooperative agreement structure.
How is the program categorized administratively?
It is categorized as a discretionary program in the health activity category and lists CFDA numbers 93.213, 93.273, and 93.866.
What is the application due date?
The original application closing date listed is 2024-11-07.
When was the notice created?
The notice was created on 2024-08-09.
Is there an award ceiling or a stated number of expected awards?
Not in the provided listing. The award ceiling and the expected number of awards are not specified in the information provided, so applicants would need to consult the full NOFO for budget limits, project period expectations, and any caps or set-asides.
What settings should the research be conducted in?
The work is intended for real-world military and veteran care settings, leveraging the PMC framework to produce operationally relevant evidence that can be adopted by the health systems serving these populations.
What is meant by "pragmatic" trials in this context?
Based on the description provided, the intent is to test approaches under real-world conditions in military and veteran health care contexts, producing evidence that is scalable and adoptable in routine practice rather than evidence confined to highly controlled research environments.
What is meant by "implementation science" projects in this context?
Based on the description provided, implementation science approaches are supported to help test and understand how non-opioid pain management solutions can be put into practice effectively within the health systems serving veterans, service members, and their families.
What makes a project a good fit for this opportunity?
A good fit is a team prepared to run a required clinical trial in real-world military and veteran care settings using pragmatic and/or implementation science methods, while working within the PMC infrastructure and collaborating with NIH staff through the cooperative agreement model.
What is the overall expected impact of funded projects?
The overall intent is to accelerate high-quality, scalable research on non-opioid pain management by leveraging shared PMC infrastructure, producing credible and operationally relevant results that are ready for adoption in the health systems that serve veterans, active-duty military personnel, and their families.
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